GLP-1 Dose Escalation Timeline

Wegovy and Mounjaro both follow a structured dose escalation schedule. Starting low reduces side effects and helps your body adjust.

Wegovy (semaglutide) dose schedule

0.25mg weekly for 4 weeks → 0.5mg for 4 weeks → 1mg for 4 weeks → 1.7mg for 4 weeks → 2.4mg maintenance. A 7.2mg pen is now also available for some patients.

Mounjaro (tirzepatide) dose schedule

2.5mg weekly for 4 weeks → 5mg for 4 weeks → 7.5mg for 4 weeks → 10mg for 4 weeks → 12.5mg for 4 weeks → 15mg maintenance.

What to expect at each stage

Side effects (nausea, fatigue) are most common in the first 1–2 weeks after a dose increase. They typically settle within 7–10 days. Most people see meaningful appetite reduction from week 2–4 onwards.